The project of Ignacio de Tomás and Fabregat of 1792 for the reconstruction of the Church of San Juan Bautista de Écija (Seville)

A partir de planos del edificio y de la documentación conservada en el Archivo de la Real Academia de San Fernando se analiza el proyecto de reconstrucción de la Iglesia de San Juan Bautista en Écija (Sevilla) realizado en 1792 por Ignacio de Tomás. Interrumpida la construcción, hoy solo quedan los restos de la que hubiera sido una importante iglesia neoclásica en el marco de una población de amplio arraigo barroc

El proyecto de Ignacio de Tomás y Fabregat de 1792 para la reconstrucción de la Iglesia de San Juan Bautista de Écija (Sevilla).

URL del artículo en la web de la Revista: https://www.upo.es/revistas/index.php/atrio/article/view/3767A partir de planos del edificio y de la documentación conservada en el Archivo de la Real Academia de San Fernando se analiza el proyecto de reconstrucción de la Iglesia de San Juan Bautista en Écija (Sevilla) realizado en 1792 por Ignacio de Tomás. Interrumpida la construcción, hoy solo quedan los restos de la que hubiera sido una importante iglesia neoclásica en el marco de una población de amplio arraigo barroco.From building plans and documents preserved in the archives of the Royal Academy of San Fernando, the reconstruction project of the Church of San Juan Bautista in Ecija (Seville) is analyzed. It was made by Ignacio Thomas in 1792. Interrupted construction, today only the remains of what would have been an important neoclassical church in the context of a village with broad baroque roots.Universidad Pablo de Olavid

PBL methodologies: BIM and 3D scanning applied to teaching in construction engineering projects

La creciente necesidad de los egresados universitarios de la educación técnica para lograr una formación integral, completa y actualizada en el uso de las tecnologías actuales y equipos avanzados, así como la adquisición de competencias relacionadas con la capacidad colaborativa y la interrelación entre disciplinas, requiere la revisión de metodologías de enseñanza y aprendizaje a estudiantes universitarios.La presente investigación recoge el estudio realizado en una asignatura de tercer curso del Grado en Edificación de la Universidad de Sevilla, sobre un total de ochenta y dos alumnos, pertenecientes a dos cursos académicos. Implementa un innovador sistema de aprendizaje, aplicando los principios de evaluación continua, fomentando el trabajo colaborativo, la participación en propuestas, y el impacto en su formación derivada de la propia experimentación con equipos tecnológicos avanzados y sistemas BIM (Building Information Modelling) presentes en el trabajo profesional contemporaneo. , con verificación de resultados, siguiendo siempre el método de aprendizaje basado en la resolución de problemas del ABP.Los resultados de este estudio indican que la comprensión e implementación de la metodología BIM y el uso de una herramienta de escaneo 3D, combinados con la metodología basada en el PBL son de gran utilidad para el desarrollo de proyectos en el campo de la ingeniería de edificación . Los datos obtenidos tras las encuestas en relación a la valoración de los alumnos sobre su aprendizaje son muy positivos y una gran mayoría de ellos afirma que tras este curso han aprendido a trabajar colaborativamente, y les ha ayudado a superar el miedo a trabajar con BIM. y herramientas de escaneo 3D

PBL methodologies: BIM and 3D scanning applied to teaching in construction engineering projects

The rising need among university graduates for technical education to achieve comprehensive, complete, and up-to-date training in the use of current technologies and advanced equipment, as well as the acquisition of skills related to collaborative abilities and the interrelationship between disciplines, requires the review of teaching and learning methodologies to university students. The current research includes the study carried out in a third-year subject of the Degree in Building at the University of Seville, on a total of eighty-two students, belonging to two academic years. It implements an innovative learning system, applying the principles of continuous assessment, encouraging collaborative work, participation in proposals, and the impact on their training resulting from their own experimentation with advanced technological equipment and BIM systems (Building Information Modelling) present in contemporary professional work, with verification of results, always following the PBL problem-solving-based learning method. The results of this study indicate that the understanding and implementation of the BIM methodology and the use of a 3D scanning tool, combined with the methodology based on the PBL are very useful for the development of projects in the field of building engineering. The data obtained after the surveys in relation to the students' assessment of their learning are very positive and a large majority of them state that after this course they have learned to work collaboratively, and it has helped them to overcome the fear of working with BIM and 3D scanning tools

Una aproximación a nuevos modelos de catalogación de planos y dibujos. Proceso y sistemática Empleada en la catedral de Sevilla.

This paper presents the analysis of the results of research work carried out for several years regarding possible ways and models for the procedure in cataloging graphic documents. We start with a thorough preliminary analysis on the existing rules, to which we understand it is subjected the cataloging of graphic documents, drawings and maps; and we suggest some ways to improve them. The management of documentary sources involves establishing mechanisms for the collection of parameters that are explicitly concerned with the cataloging rules. In the absence, in many cases, of standardized cataloging models of maps, drawings and plans, we propose a protocol based on the current rules, suitably modified basing on the experience of comprehensive cataloging work on a series of drawings and plans of Seville Cathedral, dating from the sixteenth to the twentieth centuries

El arquitecto Ignacio de Tomás y Fabregat (h. 1744-1812)

Ignacio de Tomás y Fabregat, fue un arquitecto neoclásico discípulo de Ventura Rodríguez, cuya vida transcurre entre mediados de la segunda mitad el siglo XVIII y principios del XIX, falleciendo en 1812. A pesar de que hay algunos trabajos sobre su figura, quedaba aún por analizar su biografía y su gran trayectoria profesional. El trabajo se organiza en dos partes; la primera define el momento histórico en que vivió Ignacio de Tomás, los distintos factores, sociales, económicos, culturales y artísticos que confluyeron a lo largo de su vida; y la segunda parte está dedicada a la biografía del arquitecto y a su obra, en la que se realiza un recorrido por su producción, organizada en tres etapas: la etapa formativa en la Academia de San Fernando, que transcurre desde su ingreso en 1767 hasta 1774 en que obtiene el grado de Arquitecto de Mérito; la segunda etapa en la que trabaja ya como Arquitecto de Merito al servicio de la Academia, tanto sus primeras obras en el intervalo (1776-1785), como obras dentro de la Comisión de Arquitectura en los cuatro años que transcurren desde la creación de ésta hasta su traslado a Córdoba en 1790, que son tanto obras de arquitectura religiosa y civil, como obras de ingeniería (Proyectos de construcción de puentes, proyectos de reparaciones de puentes, informes de puentes con proyectos de terceros y obras hidráulicas); la etapa andaluza, que es la más importante, en la que realiza obras de arquitectura religiosa, tanto para el arzobispado de Córdoba como para el de Sevilla, así como obras de arquitectura civil. En la tesis se analizan con mayor detenimiento sus cinco principales proyectos que son el Palacio de la Mosquera en Arenas de San Pedro (Ávila), el puente sobre el río Alberche en Escalona (Toledo), la iglesia de Santa María en Cabra del Camp (Tarragona), el murallón de la ribera (Córdoba), y la iglesia de San Juan Bautista en Écija (Sevilla)

Mexican BRCA1 founder mutation: Shortening the gap in genetic assessment for hereditary breast and ovarian cancer patients.

The deletion of exons 9 to 12 of BRCA1 (9-12 del BRCA1) is considered a founder mutation in the Mexican population. We evaluate the usefulness of the target detection of 9-12 del BRCA1 as the first molecular diagnostic strategy in patients with Hereditary Breast and Ovarian Cancer (HBOC). We performed the genetic assessment of 637 patients with suspected HBOC. The region corresponding to the breakpoints for the 9-12 del BRCA1 was amplified by polymerase chain reaction (PCR). An analysis of the clinical data of the carriers and non-carriers was done, searching for characteristics that correlated with the deletion. The 9-12 del BRCA1 was detected in 5% of patients with suspected HBOC (30/637). In patients diagnosed with ovarian cancer, 13 of 30 were 9-12 del BRCA1 carriers, which represents 43%. We found a significant association between the 9-12 del BRCA1 carriers with triple negative breast cancer and high-grade papillary serous ovarian cancer. We concluded that the detection of the 9-12 del BRCA1 is useful as a first molecular diagnostic strategy in the Mexican population. In particular, it shortens the gap in genetic assessment in patients with triple negative breast cancer and ovarian cancer

Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study.

New SARS-CoV-2 variants, breakthrough infections, waning immunity, and sub-optimal vaccination rates account for surges of hospitalizations and deaths. There is an urgent need for clinically valuable and generalizable triage tools assisting the allocation of hospital resources, particularly in resource-limited countries. We developed and validate CODOP, a machine learning-based tool for predicting the clinical outcome of hospitalized COVID-19 patients. CODOP was trained, tested and validated with six cohorts encompassing 29223 COVID-19 patients from more than 150 hospitals in Spain, the USA and Latin America during 2020-22. CODOP uses 12 clinical parameters commonly measured at hospital admission for reaching high discriminative ability up to 9 days before clinical resolution (AUROC: 0·90-0·96), it is well calibrated, and it enables an effective dynamic risk stratification during hospitalization. Furthermore, CODOP maintains its predictive ability independently of the virus variant and the vaccination status. To reckon with the fluctuating pressure levels in hospitals during the pandemic, we offer two online CODOP calculators, suited for undertriage or overtriage scenarios, validated with a cohort of patients from 42 hospitals in three Latin American countries (78-100% sensitivity and 89-97% specificity). The performance of CODOP in heterogeneous and geographically disperse patient cohorts and the easiness of use strongly suggest its clinical utility, particularly in resource-limited countries

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective